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Description: Folio Views is the new generation database application that allows you to import, export,. Itâ€™s one of the most important features in version 4.7. Folio Views is a full-featured database for relational. applications for. Folio Views is built on solid. App. 4.7.1. 34.1.0.
Folio Views 4.7.2 Full Version
Description: Folio Views is the new generation database application that allows you to import, export,. Itâ€™s one of the most important features in version 4.7. Folio Views is a full-featured database for relational. applications for. Folio Views is built on solid. App. 4.7.1. 34.1.0.Effects of drug-excipient compatibility on the stability of solid dosage forms.
The present work is aimed to develop pharmaceutical formulations showing stable and complete drug release in vitro, and to assess the effects of drug-excipient compatibility on the stability of the solid state of the pharmaceutical formulations. Forty stable compounds were chosen, and 96 solid dosage forms, consisting of tablets and capsules, were prepared with variable proportions of these selected drugs and the most suitable excipients. The stability of the solid dosage forms was investigated in water for tablets and in simulated gastrointestinal fluid for capsules. The parameters measured were mean dissolution time (MDT), percent drug release in 4 h (RG4), apparent solubility (pH 1.2), fraction of the dissolved drug (fD), and pH. The selected excipients were tartaric acid, ascorbic acid, hydroxypropylmethylcellulose, and the hydrophilic polymer sodium carboxymethylcellulose. The higher the compatibility index of the drug-excipient combination, the greater the stability. The best results were obtained with a tablet formulation containing amoxicillin, excipient compatibility index=1.8, amoxicillin compatibility index=2.1, in a ratio of 20:80 (v/v) drug-excipient. Furthermore, ascorbic acid with an index of 3.2 was the best excipient for a capsule formulation. The technique of paired comparison of stability and compatibility index with a statistically significant p-value is presented.Leber congenital amaurosis and macular hole formation: A possible association.
The purpose of this study was to determine the prevalence of occult macular holes (OH